Drugs that encourage the growth of new neurons in the brain are now headed for clinical trials. The drugs, which have already shown success in alleviating symptoms of depression and boosting memory in animal models, are being developed by BrainCells, a San Diego-based start-up that screens drugs for their brain-growing power. The company hopes the compounds will provide an alternative to existing antidepressants and says they may also prove effective in treating cognitive disorders, such as Alzheimer’s.

“The fact that you might be able to take small molecules to stimulate specific cells to regenerate in the brain is paradigm-shifting,” says Christopher Eckman, a neuroscientist at the Mayo Clinic in Jacksonville, FL. “[This approach] takes advantage of the body’s innate ability to correct itself when given appropriate cues.” Eckman studies compounds that boost brain cell growth in models of neurodegenerative disease and is not involved with BrainCells.

Full Story: Technology Review

(via Tomorrow Museum)

See also: ergoloid, Albert Hoffman’s other invention.

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The latest issue of Wired is dedicated to intelligence enhancement - and it’s filled with interesting articles and tips.

Wired: Get Smarter issue.

Here’s a taste:

Fluid intelligence was previously thought to be genetically hard-wired, but the finding suggests that with about 25 minutes of rigorous mental training a day, healthy adults could improve their mental capacities.

[…]

David Geary, a professor at the University of Missouri and author of The Origin of Mind, who was not involved with the study, said training in one test generally doesn’t generate gains on a different test.

“Transfer is tough to get,” Geary said. “Training in task A doesn’t typically improve performance on task B.”

But in this case, subjects trained on a complex version of the so-called “n-back task” — a difficult visual/auditory memory test — improved their scores on a set of IQ questions drawn from a German intelligence measure called the Bochumer Matrizen-Test. (The Bochumer Matrizen-Test is a harder version of the well-known Ravens Progressive Matrices).

Initially, the test subjects scored an average of 10 questions correctly on the IQ test.

But after the group trained on the n-back task for 25 minutes a day for 19 days, they averaged 14.7 correct answers, an increase of more than 40 percent. (A control group that was not trained showed only a very slight performance increase.)

Buschkuehl’s team postulates that the n-back task improves working memory — how many pieces of information subjects can keep in their head — as well as the ability to control the brain’s attention. Fluid intelligence tests require those types of thinking, and the training improved performance in these underlying skills.

Full Story: Wired

However, they note elsewhere that Brain Age hasn’t been proved to make you smarter.

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In January, Nature launched an informal survey into readers’ use of cognition-enhancing drugs. Brendan Maher has waded through the results and found large-scale use and a mix of attitudes towards the drugs.

[…]

One in five respondents said they had used drugs for non-medical reasons to stimulate their focus, concentration or memory. Use did not differ greatly across age-groups (see line graph, right), which will surprise some. Nora Volkow, director of the National Institute on Drug Abuse (NIDA) in Bethesda, Maryland, says that household surveys suggest that stimulant use is highest in people aged 18–25 years, and in students.

Wish they’d asked about caffeine and other non-prescription stimulants as well.

Full Story: Nature.

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Life Extension - As covered previously here on Technoccult, aspirin is the best life extension drug on the market. And it’s cheap. See: Top Ten Life Extension Drugs.

Intelligence amplification - Mind machines and smart drugs never did live up to the hype, which is probably why you don’t hear much about them anymore. I actually conducted some trials with volunteers using a brain entrainment machine for my cognitive science class in college. The results: the machine didn’t do jack. I was only ever able to experiment with self-medication with smart drugs, but my general conclusion is that some of them work as stimulants (piracetum, vassopressin) but they’re not worth the money.

The good news is, there are some new high tech intelligence amplification tools on the market: “brain fitness” games like Brain Age and Lumosity. I’m not sure how much good it will do, though. See Seed Magazine’s coverage.

Virtual Reality - We’re still waiting on decent immersive VR, but the Nintendo Wii has brought some elements of VR to homes.

Brain Backups - There’s no wetware brain backup, but if you want to preserve your knowledge for all of eternity, you can try posting the contents of your brain on the web. Google and the Internet Archive (backed by Amazon) are both attempting to archive and back-up the entire web.

Space Migration - Like brain backups, this remains vaporware. But space tourism and private space programs are taking off, including one by Amazon’s founder, Jeff Bezos.

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Biogenesis Laboratories is an excellent source for smart drugs not approved by the FDA, such as piracetam and Hydergine.
Link.

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There was a time when the name R.U. Sirius was synonymous with cyberculture. His seminal magazine Mondo 2000 predated Wired, and was even more enthusiastic in its wow-gosh sexification of the new geek order. Articles predicting a slick future of nanotech parties and smart drugs were mixed in with batches of fearful predictions of terrorism, economic collapse, draconian copyright enforcement, increased surveillance and invasive advertising. But Sirius didn’t stop there: After the collapse of Mondo, he went on to write for magazines like 21C, Salon and Disinformation, and edited Getting It. He created the Revolution Party, a non-ideological anti-authoritarian political organization (”If even the alternative parties like Libertarian and Green seem a bit rigid to you, consider joining us”), and campaigned for Presidency of the United States. His latest project, The Thresher, is a political magazine.

But The Thresher is a print magazine. Sirius hardly goes online anymore, except for research. The truth is, the Godfather of GeekChic has moved on.
(more…)

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The Life Extension Foundation has posted Top ten life extension drugs. The number one drug? Asprin! (link via Memepool)

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