Drugs that encourage the growth of new neurons in the brain are now headed for clinical trials. The drugs, which have already shown success in alleviating symptoms of depression and boosting memory in animal models, are being developed by BrainCells, a San Diego-based start-up that screens drugs for their brain-growing power. The company hopes the compounds will provide an alternative to existing antidepressants and says they may also prove effective in treating cognitive disorders, such as Alzheimer’s.

“The fact that you might be able to take small molecules to stimulate specific cells to regenerate in the brain is paradigm-shifting,” says Christopher Eckman, a neuroscientist at the Mayo Clinic in Jacksonville, FL. “[This approach] takes advantage of the body’s innate ability to correct itself when given appropriate cues.” Eckman studies compounds that boost brain cell growth in models of neurodegenerative disease and is not involved with BrainCells.

Full Story: Technology Review

(via Tomorrow Museum)

See also: ergoloid, Albert Hoffman’s other invention.

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We’ve mentioned before purported benefits of the N-Back Task on fluid intelligence:

In this case, subjects trained on a complex version of the so-called “n-back task” — a difficult visual/auditory memory test — improved their scores on a set of IQ questions drawn from a German intelligence measure called the Bochumer Matrizen-Test. (The Bochumer Matrizen-Test is a harder version of the well-known Ravens Progressive Matrices).

Initially, the test subjects scored an average of 10 questions correctly on the IQ test.

But after the group trained on the n-back task for 25 minutes a day for 19 days, they averaged 14.7 correct answers, an increase of more than 40 percent. (A control group that was not trained showed only a very slight performance increase.)

Buschkuehl’s team postulates that the n-back task improves working memory — how many pieces of information subjects can keep in their head — as well as the ability to control the brain’s attention. Fluid intelligence tests require those types of thinking, and the training improved performance in these underlying skills.

Grinding points out two applications you can use to practice n-Back Tasks on your own:

Web based N-Back test (requires Microsoft Silverlight)

hback (for Linux)

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The latest issue of Wired is dedicated to intelligence enhancement - and it’s filled with interesting articles and tips.

Wired: Get Smarter issue.

Here’s a taste:

Fluid intelligence was previously thought to be genetically hard-wired, but the finding suggests that with about 25 minutes of rigorous mental training a day, healthy adults could improve their mental capacities.

[…]

David Geary, a professor at the University of Missouri and author of The Origin of Mind, who was not involved with the study, said training in one test generally doesn’t generate gains on a different test.

“Transfer is tough to get,” Geary said. “Training in task A doesn’t typically improve performance on task B.”

But in this case, subjects trained on a complex version of the so-called “n-back task” — a difficult visual/auditory memory test — improved their scores on a set of IQ questions drawn from a German intelligence measure called the Bochumer Matrizen-Test. (The Bochumer Matrizen-Test is a harder version of the well-known Ravens Progressive Matrices).

Initially, the test subjects scored an average of 10 questions correctly on the IQ test.

But after the group trained on the n-back task for 25 minutes a day for 19 days, they averaged 14.7 correct answers, an increase of more than 40 percent. (A control group that was not trained showed only a very slight performance increase.)

Buschkuehl’s team postulates that the n-back task improves working memory — how many pieces of information subjects can keep in their head — as well as the ability to control the brain’s attention. Fluid intelligence tests require those types of thinking, and the training improved performance in these underlying skills.

Full Story: Wired

However, they note elsewhere that Brain Age hasn’t been proved to make you smarter.

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